Tamiflu: Co-administration with Probenecid

It has been suggested that co-administration of Tamiflu® with another drug called probenecid could dramatically extend the world's limited supply of Tamiflu®. Probenecid reduces excretion of Tamiflu®'s active metabolite. 500mg of probenecid given every six hours doubles Tamiflu®'s maximum blood concentration and also doubles the time that Tamiflu® stays in the blood, multiplying a patient's overall exposure to the drug 2.5-fold. Probenecid was used in similar way during World War II to extend limited supplies of penicillin. The evidence for this interaction comes from a 2002 study by Roche, but was only publicized in October 2005 by a doctor who had reviewed the data.

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